SSEA-1 Expressing Enhanced Reprogramming cells |
SSEA-4 |
Cartilage-derived factor |
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[SSEA-3(+), SSEA-3(-)]
[stage-specific embryonic antigen-3] SSEA-3 is a cell surface glycosphingolipid belonging to the globo-series of glycolipids. It is identified by two monoclonal antibodies (MC631 and MC813-70) raised against 4- to 8-cell stage mouse embryos and a human teratocarcinoma cell line (Kannagi et al, 1983). During differentiation of human teratocarcinoma 2102Ep cells, the globo-series glycolipids defined by these antibodies decrease and the lacto-series glycolipids, reacting with the SSEA-1 antibody appear. This antigen is therefore considered a marker of embryonic stem cells and pluripotency
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