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SPAP1

[SH2 domain-containing phosphatase anchor protein-1] In the nomenclature of CD antigens the protein has been given the designation CD307b. Sequence analysis shows that the protein is identical with FCRL2 [Fc receptor-like-2].

The cDNA encoding this glycoprotein has been cloned by Xu et al (2001) after an EST database search for proteins containing an ITIM motif. The presence of this sequence motif suggests that SPAP1 is an inhibitory receptor.

SPAP1 has been shown to exist in various isoforms: SPAP1A (SH2 domain-containing phosphatase anchor protein-1A ... ... ... ... ... Subscribe to continue reading! ... ...

 

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