SP90 peptide |
SP5-52 |
COPA |
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This targeting peptide, SFSIIHTPILPL, has been identified in a phage display screen by Lo et al (2008). The peptide shows specific binding for hepatocellular carcinoma cells. In vivo, PC94 homes specifically to tumor tissues but not to normal visceral organs in SCID mice bearing human hepatocellular carcinoma xenografts. PC94 also recognizes the tumor tissue but not non-tumor tissue in surgical specimens from hepatocellular carcinoma patients (positive rate of 61.3 %). Liposomes coated with the peptide and loaded with doxorubicin enhance the therapeutic efficacy against hepatocellular carcinoma xenografts through enhanced tumor apoptosis and decreased
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