sp18 |
SP94 peptide |
CG5490 |
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This targeting peptide, SMDPFLFQLLQ, has been identified by phage display selection (Lu et al, 2013). SP90 specifically binds to breast cancer cells, and recognizes tumor tissues from breast cancer patients. SP90-coated liposomes efficiently deliver drugs into cancer cells through endocytosis. In tumor xenograft and orthotopic models, SP90-conjugated liposomal doxorubicin improves the therapeutic index of the chemotherapeutic drug by selectively increasing its accumulation in tumors.
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