SMAC-beta |
SMAD |
ML |
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[SMAC-mimetic, Smac mimetic compounds, Smac mimetic compound]
These agents are peptidic and non-peptidic compounds that act like SMAC protein, an endogenous pro-apoptotic protein that resides in mitochondria and is released when a cell is triggered to undergo programmed cell death (Wang, 2011). SMAC-mimetics neutralize the anti-apoptotic effects of XIAP, cIAP1, and cIAP2 and either specifically induce apoptosis in cancer cells or act as drug-sensitizers (for overview see: Obexer and Ausserlechner, 2014; Philchenkov and Miura, 2016; Fulda, 2015). The mechanisms of action differs, depending on which anti-apoptotic protein is targeted. The interaction of SMAC mimetics with
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