SM4 |
SmA |
urinary stone protein |
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Lipscomb et al (1999) have identified SM-20 as a gene that increases in expression in sympathetic neurons after NGF withdrawal. Expression of SM-20 also increases during neuronal death caused by cytosine arabinoside or the phosphatidylinositol 3-kinase inhibitor LY294002. SM-20 protein synthesis is elevated in neurons deprived of NGF compared with neurons maintained with NGF. Expression of SM-20 in sympathetic neurons causes cell death in the presence of NGF.
SM-20 is the rat homolog of the Caenorhabditis elegans gene EGL-9 [egg laying abnormal-9
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