SKW6.4 |
SKWQHQQDSCRKQLQGVNLTPCEKHIMEKIQGRGDDDDDDDDD |
alpha-2-Heremans-Schmid glycoprotein |
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(SKW6.4) A human B-lymphoblastoid EBV-transformed cell line. It is used, among other things, for detecting B-cell differentiation factors (see: BCDF), BIF (B-cell inducing factor), or TRF (T-cell replacing factors) in bioassays by measuring the induction of the synthesis of immunoglobulins (IgM). SKW6-Cl4 cells do not respond to B-cell growth factors (see: BCGF).
The cells appear to secrete IL1 into the conditioned medium and differentiate into IgM-secreting cells in response to exogenous IL1
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