SKMYGFGLamide |
SKPs |
UL18 |
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This human neuroblastoma cell line can be propagated continuously in mitogen-free medium. The cells secrete large amounts of IGF-2 into the conditioned medium (>50 ng/mL). The cells also express type 1 IGF receptors. In the absence of other mitogens, cell proliferation is blocked by an antibody directed against the IGF receptor, suggesting the existence of an autocrine growth control loop (El-Badry et al, 1989). SK-N-AS cells engineered to express the trkA receptor proliferate in response to NGF, change their morphology, and downregulate expression of IGF-2 (Kim et al, 1999).
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