SIGLEC-10 |
SIGLEC-12 |
Apoptosis inhibitor 6 |
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[sialic acid binding immunoglobulin-like lectin 11] This protein is a member of a family of type 1 transmembrane proteins. They are cell surface lectins that have the ability to bind to sialic acids and mediate interactions between proteins and carbohydrates (see also: SIGLECs). Several studies describing the sialoside specificities of individual SIGLECs have been reported (Blixt et al, 2003; Rapoport et al, 2006).
The SIGLEC-11 protein (686 amino acids) (Angata et al, 2002) is expressed in various organs. Intense staining is observed in chronically inflamed tissues. The protein does not seem to be expressed in peripheral blood leukocytes. Expression has been observed in Kupffer cells, intestinal lamina propria macrophages, microglial cells, perifollicular
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