SH3BP1 |
SH3 containing Lymphocyte Protein |
NKB |
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(approved gene symbol) [SH3 domain-binding protein 5] The gene encoding SHRBP5 has been cloned as an interactor with BTK [Bruton's tyrosine kinase] (Matsushita et al, 1998). It is known also as Sab [SH3 domain-binding protein that preferentially associates with BTK] (Matsushita et al, 1998). It was cloned as an interactor with c-Jun N-terminal kinase (JNK) (Wiltshire et al, 2002). Sab is associated with mitochondria, where it co-localizes with a fraction of active JNK
SH3BP5 negatively regulates BTK function in B-cells (Yamadori et al, 1999) and targets JNK to mitochondria where SH3BP5 may behave as a platform for the JNK-mediated signaling cascade (Yamadori et al, 1999).
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