SCIN |
SCIN-C |
Orcokinin |
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[Staphylococcal complement inhibitor B] SCIN-B, encoded by the scb gene, shares 48 % homology with SCIN [staphylococcal complement inhibitor] (Jongerius et al, 2007). SCIN-B is a secreted protein that effectively blocks calcium mobilization mediated by complement factor C5a. SCIN-B strongly blocks phagocytosis of the pathogen by neutrophils. SCIN-B also strongly prevents deposition of C3b/iC3b in normal human serum. SCIN-B inhibits complement by stabilization of C3 convertases, which is similar to the inhibitory mechanism of SCIN.
For other relevant entries see also the Pathogenicity/Virulence Factors Dictionary section of this encyclopedia.
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