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SCAIF-1

[shark cartilage angiogenesis inhibitory factor-1] This protein of 18 kDa has been isolated from shark cartilage (Shen et al, 2000). It specifically inhibits the proliferation of endothelial cells, and strongly blocks endothelial cell movement and angiogenesis in the Chicken chorioallantoic membrane assay. Systemic administration of SCAIF-1 suppresses the growth of Lewis lung carcinoma implanted in C57BL/6 mice.

See also: Angiogenesis Dictionary section of this encyclopedia for other entries directly bearing on factors and processes involved in the generation of new blood vessels.

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