SA-7 |
SA-36 |
damage-regulated autophagy modulator 2 |
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This anticancer peptide (also: peptide SA12) with the sequence Ser-Val-Pro-Leu-Phe-Asn-Phe-Ser-Val-Tyr-Leu-Ala [SVPLFNFSVYLA] has been identified by phage display methods, using the proteome of SKBr-3 breast cancer cells. The peptide significantly inhibits proliferation and induces cell death by apoptosis in these cells (Yang et al, 2015). Yang et al (2018) have reported that SA12 peptide inhibits proliferation of breast cancer cell lines MCF-7 and MDA-MB-231 through G0/G1 phase cell cycle arrest.
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