Roof plate cells

this term refers to a specialised cell type defined by its anatomical location, i.e. the roof plate, which is the most dorsal region of the developing spinal cord. These cells stretch along the dorso-ventral axis, express Nestin, and have been referred to also as dorsomedial Nestin-positive radial glia. Roof plate cells give rise to neural crest cells that subsequently develop into neurons and glial cells of the nervous systems, pigment-containing cells of the epidermis, and chromaffin cells of the adrenal gland (for overview see: Shinozuka T and Takada S, 2021).

Lee et al (2000) have reported that the roof plate is essential for specifying multiple classes of neurons in the ... ... ... ...
 
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Entry last modified: January 2023