Rhnull phenotype

this phenotype pertains to the complete absence of Rhesus blood group antigens (Rhesus D antigen, Rhesus C-antigen, Rhesus c antigen, Rhesus E-antigen, Rhesus e antigen) (for early reports see: Vos et al, 1961; Schmidt and Vos, 1967; Sturgeon, 1970; Seidl S et al, 1972; Levine et al, 1964; Ishimori T and Hasekura H, 1967).

The complete lack of Rh proteins is caused frequently by mutations in the Rhesus-associated protein RHAG (then termed the regulator Rhnull phenotype). While erythrocyte RHAG is not associated with any blood group antigen, it is important for targeting RHCE and RHD ... ... ... ...
 
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Entry last modified: January 2021