Rabies virus phosphoprotein |
Rabies virus protein G |
Amacrine cells |
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[Rabies virus phosphoprotein] This nonstructural protein of Rabies virus plays an essential role in genome replication as the polymerase cofactor through interaction with viral N-protein (Mavrakis et al, 2004).
In addition, the protein plays an important role in immune evasion as a major antagonist of antiviral type 1 interferon signaling (IFN-alpha, IFN-beta). The protein binds to STAT proteins such as STAT1 or STAT2 (Vidy et al, 2005; Brzózka et al, 2006) and prevents these complexes from entering the nucleus (Pasdeloup et al, 2005). The protein also binds to IRF2 (Brzózka et al (2005). Wiltzer et al (2014) have reported that the introduction of mutations in the P protein that prevent the interaction with
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