RVSMC |
RVVDLMAYMASKE |
Enhancers |
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This bioactive peptide has been isolated from Russell's viper (Daboia russelii russelii) venom (Mukherjee et al, 2014). RRVAP promotes angiogenesis and induces endothelial cell migration at 50 ng/mL. At higher concentration, the peptide progressively decreases wound healing. RVVAP (1.0 μg/mL) is non-cytotoxic to U87-MG, HeLa and HT-29 cells, but at higher concentrations (above 500 ng/mL) the peptide induces chromosomal aberrations and delays in cell cycle kinetics of Chinese hamster ovary cells.
See also: Angiogenesis Dictionary
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