RVG peptide

[rabies virus glycoprotein peptide] This peptide, described originally as CVS(175-203) (Rabies virus strain CVS (challenge virus standard)) (Lentz, 1990) is a fragment of rabies virus glycoprotein, corresponding to RVG(175-203) [rabies virus glycoprotein(175-203)] with the sequence YTIWMPENPRPGTPCDIFTNSRGKRASNG. This fragment binds to the alpha-1-subunit of the nicotinic acetylcholine receptor.

Exploiting the specific binding of RVG peptide to the acetylcholine receptor on neuronal cells, RVG peptide has been used as a targeting peptide permitting delivery of cargo proteins to the brain or cells expressing the receptor. The terms RVG-9R and RVG-9dR refer to RVG peptides ... ... ... ...
 
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Entry last modified: June 2015