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RUN domains

[RUN domain]

RUN domains are named after three genes in which they were identified first (RPIP8 [RaP2 interacting protein 8], UNC14, and NESCA [New molecule containing SH3 at the carboxy-terminus]) The RUN domain is a less conserved protein motif of approximately 70 amino acids (Callebaut et al, 2001), identified originally in several proteins that have been linked to the function of small GTPases of the Ras superfamily, which play a crucial role in a variety of cellular events, including cell proliferation, cell morphological change, intracellular membrane trafficking, and nucleocytoplasmic transport (Callebaut et al, 2001). RUN domain proteins are involved also in the regulation of cell polarity and membrane trafficing (Yoshida et al, 2011; Kitagishi and Matsuda, 2113).

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