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FCN3 |
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An established rat insulinoma cell line. The cells have been used, among other things, to develop a bioassay for IL1. The cells respond to murine and human IL1-beta and IL1-alpha in the range of 0.1 to 1 unit/mL to produce nitric oxide.
Nitric oxide formation is not induced by IL2, IL4, IL6, IL9, IL11, IL15, TNF-alpha, IFN-gamma, and bacterial lipopolysaccharides either alone or in combination and these cytokines do not significantly potentiate or attenuate the response to
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