r150 |
RAALPPGFTPFR |
ALDSLGGFQVHGW |
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[Rheumatoid arthritis antigen A47] This protein of 47 kDa is synthesized by the chondrocytic cell line HCS-2/8 and its expression is induced by TGF-beta (Hattori et al, 1998). Hattori et al (2003) have reported that expression of RA-A47 is downregulated in chondrocytes by TNF-alpha and that RA-A47 is found also on the surface of chondrocytes where it is recognized as an antigen in the serum of rheumatoid arthritis patients. Treatment of rabbit chondrocytes and human chondrosarcoma cells HCS-2/8 by antisense oligonucleotides significantly reduces the expression of RA-A47. This downregulation is associated with a strong induction of
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