R-spondin-3 |
R-spondins |
eosinophil cationic protein |
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[Roof plate-specific spondin-4] abbr. Rspo4. R-spondin-4 has been identified independently as Cristin-4 [cysteine-rich single thrombospondin domain-containing protein-4] (Nam et al, 2006). The human protein is encoded by open reading frame C20orf182 [chromosome 20 open reading frame 182].
R-spondin-4 has been identified by (Kazanskaya et al, 2004) who demonstrated that the protein is a regulator of beta-catenin, which plays a role in canonical Wnt signaling. The receptors have been identified as LGR4, LGR5, and LGR6.
Kim et al (2008) have reported that R-spondin-4 is a general regulator of
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