Pulmonary macrophages |
pulmonary neuroepithelial bodies |
Ala-His-Arg-Tyr-His |
||
abbr. PNECs. This specialised type of epithelial cells is found in the airway epithelium of human and animal lungs, where they are enriched at airway branch points (Scheuermann DW, 1997; for general overview see: Noguchi M et al, 2020). These cells, described originally as Helle Zellen (German for Light cells or Bright cells) (Fröhlich F, 1949), contain secretory dense-core vesicles (Feyrter F, 1954), appear early during lung development (Stahlman MT et al, 1985; Ten Have-Opbroek AA, 1991; Garg A et al, 2019), and may occur either as solitary cells or in the form of cell clusters (~3 to 20 cells in mouse lungs) termed NEBs [
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