Prothrombin accelerator |
Prothymocyte Differentiating Activity |
Ohmyungsamycin A |
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By using a simple in vitro angiogenesis assay system based on the proliferation of bovine capillary endothelial cells a protein was purified from the serum of New Zealand White rabbits that showed anti-endothelial cell proliferative activity. The purified angiogenic inhibitor inhibited the growth of bovine capillary endothelial cells and was non cytotoxic. This molecule was identified as a prothrombin kringle-2 domain (fragment-2). Prothrombin kringle-2 domain can be released from prothrombin by cleavage with factor Xa, which also yields bioactive thrombin (Lee et al, 1998).
Ryu et al (2002) have reported that Prothrombin kringle-2 domain causes cell activation
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