PUMA-beta |
PUMP |
uncoordinated locomotion-51 |
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[protein upregulated in macrophages by IFN-gamma] This murine protein has been identified by Schaub et al (2001). The expression of this protein is upregulated in macrophages in response to IFN-gamma. PUMA-G protein is most similar to the human orphan G-protein-coupled receptor HM74 (73 % identity) and considered the murine homolog of HM74. The protein is known also as GPR109B [G-protein-coupled receptor-109B].
Taggart et al (2005) have shown that the fatty acid-derived ketone body (D)-beta-hydroxybutyrate ((D)-beta-OHB) acts as an endogenous ligand, which specifically activates the PUMA-G receptor and inhibits
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