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PT-1

[potamin-1] PT-1 is a 5.6 kDa trypsin-chymotrypsin protease inhibitor isolated from the tubers of the potato (Solanum tuberosum L cv. Gogu) (Kim et al, 2005). PT-1 (DICTNCCAGTKGCNTTSANGAFICEGQSDPKKPKACPLNCDPHIAYA) possesses antimicrobial activity but lacks hemolytic activity. PT-1 strongly inhibits pathogenic microbial strains, including Candida albicans, Rhizoctonia solani, and Clavibacter michiganense subsp. michiganinse. The N-terminal sequence of PT-1 has 62 % homology with a serine protease inhibitor belonging to the Kunitz family, and the peptide inhibits chymotrypsin, trypsin, and papain.

For other proteins/peptides with functions in innate immunity and/or antimicrobial activities see also: Innate immunity and defense peptides Dictionary.

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