PF4 |
PF4A |
cellular repressor of E1A-stimulated genes |
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[platelet factor-4(47-70)] This fragment of PF4 (NGRKICLDLQAPLYKKIIKKLLES), identified by Jouan et al (1999), contains the heparin-binding lysine-rich site (for comparison see also the corresponding sequence for PF4-ALT derived from the non-allelic gene CXCL4L1.
The peptide has been shown to inhibit bFGF or VEGF function. It inhibits bFGF or VEGF binding to endothelial cells. It inhibits bFGF or VEGF binding in heparan sulfate-deficient CHO cells transfected with FGFR1 or VEGFR2 cDNA. The
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