PF-18 |
PF-382 derived BFU-E growth inducer |
Pleurocidin NRC-09 |
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This biochemically uncharacterized factor of 47 kDa is secreted into the conditioned medium of PF-382 cells, a human T-cell line obtained from pleural effusions of a child with T-acute lymphoblastic leukemia (Pegoraro et al, 1985). The factor inhibits the in vitro growth of myeloid (CFU-GM) and erythroid (BFU-E) progenitor cells (see also: hematopoiesis). The same effect is obtained when irradiated PF-382 cells are co-cultured with the hemopoietic precursors (Bellone et al, 1987, 1988).
PF-382 cells also secrete two suppressor factors (115 and 80 kDa) that suppress T-cell proliferation (Ponzoni et al, 1988) and a
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