PCI-50-derived growth-promoting activity |
PCINP |
SAAL |
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[PCI domains]
(for Proteasome, COP9, Initiation factor-3) This domain of approximately 200 amino acids, which is generally localised at the extreme C-terminus of the corresponding protein. It is a protein-protein interaction motif (Hoffmann and Buchner, 1998). All proteins containing this domain appear to be part of large multi-protein complexes. The domain occurs in multiple components of the regulatory 26S proteasome, which plays a major role in eukaryotic protein breakdown, especially for proteins tagged with ubiquitin, as well as in several other characterised protein families (Maytal-Kivity et al, 2003; Kim et al, 2001).
For information on other protein domains and sequence motifs see also the
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