OvHV-2 IL10

[ovine herpesvirus 2 IL10] This IL10 homolog is encoded in the genome of ovine herpesvirus 2 (Jayawardane G et al, 2008).

Unlike IL10 homologs from other gammaherpesviruses, the OvHV-2 peptide sequence is highly divergent from that of the host species. The gene is unique, however, in that it has precisely retained the original cellular exon structure The sizes of the introns are dramatically reduced. OvHV-2 protein is a non-glycosylated, secreted protein. Functional assays show that this viral IL10, in a similar way to ovine IL10, stimulates mast cell proliferation and inhibits ... ... ... ...
 
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Entry last modified: March 2011