osteoclast-like cells |
Osteoclastogenesis inhibitory factor |
MRP-S29 |
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[Osteoclast-like giant cell]
abbr. often OCGC or OGC. This cell type, which resembles osteoclasts at both the morphologic and immunohistochemical levels, are nonneoplastic multinucleated giant cells that are relatively common in neoplasms of various organs, such as skin, thyroid gland, ovary, breast, kidney, prostate and especially pancreatic adenocarcinoma. The cells express CD68 and are thought by most authors to be of histiocytic origin and are reactive in nature. Features suggesting the benign nature of these cells include: bland appearance identical to osteoclasts in osteoclastoma, immunostaining patterns that are different from the malignant cells
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