OP9

a murine stomal cell line established from newborn B6C3F1 op/op mouse calvaria (Kodama et al, 1994). These cells do not produce functional M-CSF due to the osteopetrotic mutation in the gene encoding M-CSF.

Coculture of OP9 cells with mouse embryonic stem cells (ES cells) has been used to develop an efficient differentiation induction system allowing preferential differentiation of ES cells into hematopoietic cells other than the lineage of monocytes and macrophages (see also: hematopoiesis ... ... ... ...
 
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Entry last modified: January 2013