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Nuocytes

[nuocyte]

This cell type has been identified and functionally characterized by Neill et al (2010). Nuocytes are said to constitute a discrete type of innate type-2 immune effector leukocytes (Th2 cells). Nuocytes expand in vivo in response to IL25 and IL33, and represent the predominant early source of IL13 during helminth infection with Nippostrongylus brasiliensis. In the combined absence of IL25 and IL33 signaling, nuocytes fail to expand, resulting in a severe defect in worm expulsion. This is rescued by the adoptive transfer of in vitro cultured wild-type nuocytes but not by nuocytes lacking IL13.

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