Nogo receptor-like 3 |
NOL3 |
chemokine receptor expressed in activated monocytes |
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(meaning 'nocturnal' in Bengali); abbr. Nkt. This protein, identified by Serngupta et al (2019), is encoded by Drosophila melanogaster gene CG14141. Noktochor is a secreted protein of 162 amino acids that is required for normal sleep. Knock-out flies lacking expression of the protein or those with selective knock-down of its expression in either neurons or astrocytes have decreased and fragmented night sleep, indicative of a non-redundant requirement in both cell types.
Knock-down of Noktochor expression has no observable effect on development, viability, or gross nervous system morphology. Noktochor is required in fly astrocytes
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