Nidogen |
nidoviral uridylate-specific endoribonuclease |
FDC protein |
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also: NID [Nidogen]; approved gene symbol NID1. Nidogen-1 is an extracellular matrix protein identified independently in the mouse as a 150 kDa sulfated basement membrane glycoprotein termed entactin (Durkin et al, 1988). The human gene encoding Nidogen-1 has been characterized by Nagayoshi et al (1989) and Zimmermann et al (1995). Nidogen-1 forms a highly stable noncovalent complex with laminin and also binds collagen-4 (Chung and Durkin, 1990). Gersdorff et al (2005) have reported binding of Nidogen-1 to laminin-gamma-3. Nidogen-1 also forms high-affinity complexes with Perlecan (Kvansakul et al, 2001). Knock-out mice
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