neutrophil-immobilizing factor-2 |
Neutrophil migration inhibitory factor |
cryptides |
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[Ancyclostoma caninium Neutrophil inhibitory factor] abbr. NIF (a term with multiple meanings). Neutrophil inhibitory factor is a 41 kDa protein (257 amino acids) from the canine hookworm Ancyclostoma caninium (Moyle et al, 1994). The protein has no significant sequence homologies to previously reported proteins but shows sequence homology with hookworm platelet inhibitor isolated from the same organism.
Neutrophil inhibitory factor binds CD11b / CD18 and inhibits CD11b / CD18 dependent adhesion of neutrophils (Moyle et al, 1994). NIF prevents lung vascular injury dependent on the activities of neutrophils by inhibiting adhesion of neutrophils to the
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