NKLP27 |
NK-lymphocytes |
Metalnikowin-3 |
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[natural killer lysis resistance inducing factor] This biochemically uncharacterized factor of approximately 12.6 kDa is secreted by concanavalin A-activated rat spleen cells (Saxena et al, 1987, 1988, 1989). It is distinct from IL2 or interferons. NK-LRIF induces resistance against NK-cell mediated lysis in some lymphoma cell lines. The factor also induces the expression of MHC class 1 antigens and reduces the growth rates of lymphoma cells.
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