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NIF-1

[neutrophil-immobilizing factor-1] This protein of 41 amino acids has been isolated from the 22,000 g supernatant of sonicates of human neutrophils (Watt et al, 1983). The sequence of 20 of the aminoterminal amino acids of NIF-1 is identical with that of NIF-2, but NIF-2 possesses an additional alanine at the aminoterminus. NIF-1 inhibits random migration of human neutrophils (see also: motogenic cytokines) and chemotaxis to diverse stimuli (C5a and fMLP) in a concentration-dependent manner. NIF-1 is not cytotoxic for neutrophils. It does not alter their phagocytosis behaviour or release of lysosomal enzyme. It also does not inhibit chemotaxis of ... ... ... ... ... Subscribe to continue reading! ... ...

 

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