Naf1-beta |
NAG14 |
CD45RA |
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[NSAID activated gene-1; Nonsteroidal-anti-inflammatory drug activated gene-1] This gene has been identified by Baek et al (2001). It is expressed in HCT-116 cells (human colorectal cells) treated with nonsteroidal anti-inflammatory drugs (NSAIDs). The encoded protein promotes cell death by apoptosis. In the HCT-116 cells, NAG-1 expression is increased and cell death by apoptosis is induced by treatment with some NSAIDs in a concentration and time-dependent manner. NAG-1 transfected cells exhibit increased basal apoptosis, increased response to NSAIDs, and reduced soft agar cloning
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