Monocyte-derived granulocyte-activating mediator |
monocyte-derived hepatocyte-like cells |
mucosal mast cells |
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abbr. MDGF (a term with multiple meanings). This factor of 16 kDa is produced by human monocytes. It is a monomeric form of PDGF (Pencev and Grotendorst, 1988). MDGF may have a different primary structure since it exhibits different sensitivities to either formic acid or CNBr cleavage compared to PDGF-A or PDGF-B chains.
Another biochemically uncharacterized factor (pI 5.0; approximately 33-42 kDa) is found in conditioned medium of mitogen-stimulated human peripheral blood lymphocytes. It stimulates the proliferation of fibroblasts and smooth muscle cells. This activity is enhanced by IL1
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