MOMP |
Monad |
YPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRYamide |
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[monocytic adaptor] Mona is an adaptor molecule for the activated phosphorylated M-CSF receptor fms that contains one SH2 domain and two SH3 domains (Bouretta et al, 1998). The protein is related to the GRB2 adaptor. Mona is a competitor of GRB2 for binding to M-CSF receptor. Mona also interacts with another adaptor, called Gab3, which is important for mediating the M-CSF receptor differentiation signal (Bourgin et al, 2002).
Mona has been identified independently as GADS [GRB2 related adapter downstream of shc], GRID [GRB2-related protein with insert domain], and
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