mitochondrion-rich cells |
Mitocryptide-2 |
proprotein |
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abbr. MCT-1; described originally as COSP-1 (see: Ueki et al, 2007). This peptide has been identified by Mukai et al (2008) as a peptide in porcine hearts that causes cell activation of neutrophils. Its primary structure (LSFLIPSGWVLSHLDHYKRSSSS) corresponds to mitochondrial cytochrome C oxidase subunit 8. Mitocryptide-1 causes chemotaxis of neutrophils and induces release of beta-hexosaminidase. These responses are observed in neutrophilic/granulocytic differentiated HL-60 cells but not in undifferentiated cells. The peptide also causes cell activation of
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