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Mafia mice

[Mafia mouse]

The acronym Mafia refers to macrophage-Fas-induced apoptosis. These transgenic mice have been generated by Burtnett et al (2004). These mice express an inducible suicide gene, which allows systemic and reversible elimination of macrophages. A macrophage-specific fms promoter is used to express enhanced green fluorescent protein and a drug-inducible suicide gene that leads to cell death by apoptosis mediated by FAS in resting and cycling cells of the macrophage lineage. Transgenic mice are fertile, of normal weight, and show no abnormal phenotype before drug exposure. The ... ... ... ... ... Subscribe to continue reading! ... ...

 

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