Macrovipera lebetina IC2 |
MACs |
S-endo 1 |
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Macrovipera lebetina IC1 [Increasing Capillary1] is a protein that belongs to the snake venom VEGF family (see: also svVEGF, VEGF-F). It has been isolated from the venom of Macrovipera lebetina, based on its ability to cause vascular leakage. IC1 has a marked specificity for the VEGF receptor VEGFR2, with an affinity in the nanomolar range. The protein also binds to neuropilin-1 and neuropilin-2 with an affinity in the micromolar range (Aloui et al, 2009).
A second distinct protein, termed Macrovipera lebetina IC2 [Increasing Capillary2] has the same properties as IC1.
See also: Angiogenesis Dictionary
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