Macrophage cytotoxin |
Macrophage-dependent fibroblast stimulating activity |
IL13 receptor-alpha-2 |
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abbr. MDF (a term with multiple meanings). Two species of MDF (13 kDa and 66 kDa) have been described. MDF activity is found in the conditioned medium of a number of murine normal and tumor cell lines. It reversibly blocks the enhanced oxygen metabolism induced by IFN-gamma, the production of nitrogen oxides, the capacity to kill intracellular parasites, and the expression of Ia antigens in macrophages and monocytes. Activated macrophages become deactivated (see also: cell activation).
The 66 kDa protein appears to be identical with albumin according to the known N-terminal sequences. The other protein is not identical with
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