MPV G Glycoprotein |
MPV viral chemokine inhibitor |
Gamma-1-globin |
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[MPV viral chemokine inhibitor; Monkeypox virus viral chemokine inhibitor] This viral chemokine receptor (see also: viroceptors, vCCI) is encoded in the genome of Monkeypox virus (MPV), an orthopoxvirus with considerable homology to variola major, the etiologic agent of smallpox. MPV vCCI is expressed abundantly and secreted from virus-infected cells. MPV vCCI efficiently binds rhesus MIP-1-alpha. MPV vCCI completely inhibits chemotaxis mediated by MIP-1-alpha. In vivo recruitment assays in rhesus macaques show a decrease in the number of CD14(+) cells responding to MIP-1-alpha when MPV vCCI is present, suggesting MPV vCCI effectively inhibits
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