Micasin-2 |
michelob_x(mx) |
wa-1 |
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[Mini-ICE; Mini-IL1-beta Convertase] This murine protein has been designated Caspase-14. The cDNA encodes a protein of 257 amino acids. The protein displays significant homology to other caspases but it lacks an aminoterminal prodomain or a caspase recruitment domain. Procaspase-14 can be processed in vitro by caspase-8 and caspase-10 but not by other caspases. It can be cleaved also by granzyme B. In vivo, caspase-14 is activated after engagement of APO-1 or TRAIL.
MICE is one of the cysteine proteases related to IL1-beta Convertase
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