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MHC AF

[MHC augmenting factor] This factor of 35 kDa was isolated from the conditioned medium of Concanavalin A-activated human peripheral blood mononuclear cells (Puri and Saxena, 1998).

MHC AF augments the expression of major histocompatibility complex 1 antigens on K562 and gastric carcinoma tumor (HR) cells.

The effect of MHC AF is not observed with IFN-alpha, IFN-beta, TNF, IL2, IL4, IL5 and IL7. IFN-gamma shows significant MHC AF activity and the activity is partially blocked by antibodies against IFN-gamma.

Purified MHC AF preparations do not have any activity in WISH ... ... ... ... ... Subscribe to continue reading! ... ...

 

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