MGVKFFTLSTRFFPSVQRAVPLWTNS |
MH2 domain |
FKSG37 |
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[MH1 domains, MH2 domains]
[MAD homology 1 domain] This domain is found in SMAD proteins, evolutionarily conserved proteins identified as mediators of transcriptional activation by members of the TGF-beta superfamily of cytokines. It is separated by a poorly conserved linker sequence from a second domain, designated MH2 domain.
The amino-terminal MH1 domain functions as a sequence-specific DNA-binding domain (Kim et al, 1997; Yingling et al, 1997; Zawel et al, 1998; Dennler et al, 1998; Shi et al, 1998; Chai et al, 2003; Grishin, 2001). The carboxyl-terminal MH2 domain
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