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MERS-CoV ORF4a

[Middle East respiratory syndrome Coronavirus ORF4a] this open reading frame in the genome of MERS-CoV [Middle East respiratory syndrome Coronavirus], the causative agent of severe-to-fatal pneumonia, encodes one of several viral accessory proteins. MERS-CoV ORF4a antagonises type 1 interferon responses by blocking pattern recognition receptor MDA-5 (Niemeyer et al, 2013; Yang et al, 2013). It interacts with PACT [protein activator of the interferon-induced protein kinase] in an dsRNA-dependent manner, inhibiting PACT-induced activation of RIG-I and MDA-5 but does not affect the activity of downstream effectors such as RIG-I, MDA-5, MAVS, TBK1 [ ... ... ... ...
 
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Entry last modified: March 2020



 
 
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